AMGEN ACQUIRES DARK BLUE THERAPEUTICS, BOLSTERING ONCOLOGY PIPELINE

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• Acute myeloid leukemia remains one of the most difficult cancers to treat, and there is an urgent need for new mechanisms capable of changing the trajectory of this disease

  80% confidence

• Preclinical data in leukemia models demonstrate promising anti-cancer activity and mechanistic differentiation from currently available therapies, establishing rationale for single-agent and combination use to overcome treatment resistance and enhance durability of remission

  80% confidence

• The acquisition complements and extends Amgen's research in targeted protein degradation and leukemia therapeutics, advancing their strategy to invest early in rising medicines for novel therapeutic targets

  80% confidence

• The adjacency of this program to Amgen's expertise in cancer biology will propel MLLT1/3-targeting medicines to clinical investigation for AML patients

  80% confidence

• Amgen expects to integrate Dark Blue Therapeutics into its existing research organization, further strengthening the company's early oncology discovery efforts

  80% confidence